Glial cell‐derived neurotrophic factor promotes dental pulp stem cell migration
نویسندگان
چکیده
منابع مشابه
Glial Cell Line-Derived Neurotrophic Factor Promotes Survival and Proliferation of Dental Pulp Cells
This study investigated the effects of glial cell line-derived neurotrophic factor (GDNF) on dental pulp stromal cells (DPCs). Cultures of DPCs expressed GDNF as well as its receptors, GFR1 and RET. Addition of recombinant GDNF to cultures in serumcontaining medium did not significantly affect DPC growth; however, GNDF dosedependently increased viable cell number under serum-free culture condi...
متن کاملSimvastatin Promotes Dental Pulp Stem Cell-induced Coronal Pulp Regeneration in Pulpotomized Teeth.
INTRODUCTION Pulpotomy is a specific treatment used to save root pulp, in which only the inflamed coronal pulp is removed and capping materials are placed. Our study aims to study the effect of simvastatin (1) on the proliferation and differentiation of dental pulp stem cells (DPSCs) and (2) on DPSC-induced pulp regeneration after pulpotomy. METHODS DPSCs were treated with different concentra...
متن کاملThe Effects of Progesterone on Glial Cell Line-derived Neurotrophic Factor Secretion from C6 Glioma Cells
Objective(s)Progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. In recent years, the neuroprotective effects of progesterone have attracted growing interest. Glial cell line-derived neurotrophic factor (GDNF), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
متن کاملDentin phosphophoryn promotes cellular migration of human dental pulp cells.
Dentin phosphophoryn (DPP) is a dentin sialophosphoprotein gene product that has an RGD motif and repeat sequences of aspartic acid and phosphoserine. To date, the function of DPP in the early stage of reparative dentin formation still remains unclear. The objective of this study was to evaluate the effects of DPP on pulp cell migration and proliferation. DPP promoted cell migration in a concen...
متن کاملEDTA conditioning of dentine promotes adhesion, migration and differentiation of dental pulp stem cells.
AIM To evaluate the effect of dentine conditioning on migration, adhesion and differentiation of dental pulp stem cells. METHODOLOGY Dentine discs prepared from extracted human molars were pre-treated with EDTA (10%), NaOCl (5.25%) or H2 O. Migration of dental pulp stem cells towards pre-treated dentine after 24 and 48 h was assessed in a modified Boyden chamber assay. Cell adhesion was evalu...
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ژورنال
عنوان ژورنال: Journal of Tissue Engineering and Regenerative Medicine
سال: 2017
ISSN: 1932-6254,1932-7005
DOI: 10.1002/term.2490